Durant was born in in Wales and obtained his first degree and Ph. At the time he had a particular interest in guanidine chemistry which proved to be invaluable in the development of cimetidine. William Duncan who was Director of Research gave his unwavering support through all the low periods and when closure of the research program seemed likely.
John C. Following the successful work leading to cimetidine, he moved into the area of selective thyromimetics and later became Head of Medicinal Chemistry. Michael Parsons provided the essential pharmacological support characterizing the new receptor and the antagonist activity of the compounds made. Lee Webb was born in Australia in George Wellman was born in Detroit in He entered Kalamazoo College in and received a B.
Staying in chemistry and in Kalamazoo, he continued his studies at Western Michigan University where he received a M. He was awarded an NIH postdoctoral fellowship and continued his postdoctoral research at the University of Michigan.
Charles E. Berkoff and Elvin L. Anderson initiated the work to identify more efficient manufacturing processes. Bing Lam, Wilford Mendelson, Joseph Lewis, and Cliff Labaw worked with Wellman and Webb and were key contributors to the search for efficient processes for manufacturing cimetidine.
The plaques commemorating the events read:. Pioneering work by scientists in the laboratories of this company led to the first clinically effective inhibitor of gastric acid secretion. The worldwide introduction of cimetidine Tagamet revolutionized the treatment of peptic ulcers by dramatically reducing the need for surgical intervention.
The work is recognized as the classic example of the systematic modification of a natural messenger substance histamine to create a therapeutically useful blocking agent. Effective commercialization of this discovery was greatly facilitated by the subsequent investigation and design of novel synthetic routes, which led to the development of an efficient chemical manufacturing process. Back to Landmarks Main Page. Learn more: About the Landmarks Program.
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Gimping around on one foot was uncomfortable for a week or so. Within a few days the warts began to get smaller; some of the little ones disappeared altogether. I doubled the dose and now the warts are completely gone. It took about a month for them all to disappear. I noticed the life-long warts on his hands had vanished, and they have never come back.
It was later I had read somewhere that this drug might have been the cure. People using this approach should check in with their pharmacists about potential interactions with other drugs they may be taking.
Cimetidine does not combine well with certain other medicines. Not everyone with hard-to-treat warts will respond to Tagamet. It has been our experience that certain remedies work great for some people but not for others. Of course that is true about medications as well. We're empowering you to make wise decisions about your own health, by providing you with essential health information about both medical and alternative treatment options.
How to Get Rid of a Wart with Tagamet One reader found that taking cimetidine was an effective way to get rid of a wart on the sole of the foot. Kevin Colgan, a spokesman for Merck, said that the impact on Pepcid sales would be moderate since Tagamet was already heavily discounted to the managed care market. Merck also "sees the patent expiration of Tagamet as creating an opportunity" for the company's Medco managed care unit to offer "greater cost savings" to health plans, Mr.
Colgan said. Jerry Karabelas, head of SmithKline's North American pharmaceuticals unit, said that "the dollars will decrease" in the ulcer treatment market as a result of the expiration of Tagamet's patent.
But he said it was "still speculative" to say whether Zantac and other brands would lose sales. Promotional Efforts. Glaxo is repackaging Zantac in gelatin capsules and a liquid version. We can trace the beginning of beer far back beyond the dawn of recorded time.
Apparently, beer was the first alcoholic beverage known to civilization. Bells may be categorized as idiophones, instruments sounding by the vibration of resonant solid material, and more broadly as percussion instruments. The history and origins of beverages and the equipment used to make them. Stephen Poplawski invented the kitchen blender. Learn about the history of Bic pens and other writing instruments.
The history of the foot-powered riding machine. Benjamin Franklin is credited with creating the first pair of eyeglasses that help both near- and far-sighted people see better. The bikini was invented in and named after the Bikini Atoll in the Marshall Islands, the site of the first atomic bomb testing. The first proposition to use biological methods to treat odorous compounds came as early as Biometrics technology is used to uniquely identify or verify an individual through characteristics of the human body.
Charles Richard Drew was the first person to develop the blood bank. Non other than Levi Strauss invented blue jeans. Puzzle over the history of board games and other brain teasers. Throughout recorded history, people have used various types of materials as body armor to protect themselves from injury in combat and other dangerous situations.
George Babcock and Steven Wilcox co-invented the water tube steam boiler, a safer and more efficient boiler. The history of the boomerang. In , the Bourdon tube pressure gauge was patented by Eugene Bourdon. It's and Mary Phelps Jacob's corset was not the undergarment to wear under her new shear evening gown.
The history of dental braces or the science of Orthodontics is complex, many different patents helped to create braces as we know them today. Louis Braille invented braille printing. Brushes were used as early as 2,, years ago. The invention and history of chewing gum, bubble gum, gum wrappers, gum tins and bubble gum machines. It is not certain who invented the first bulldozer, however, the bulldozer blade was in use before the invention of any tractor.
As an inventor, Robert Bunsen developed several methods of analyzing gases, however, he is best known for his invention of the Bunsen burner. Ebenezer Butterick, together with his wife Ellen Augusta Pollard Butterick, invented the tissue paper dress pattern. Learn about the invention of early clocks, calendars, the quartz watch, timekeeping devices and the science of time.
Timelines covering calculator patents since Learn about the history of Texas Instruments, the origins of the electronic calculator, the hand-held calculator and more.
The history of the camera, including Camera Obscura, photography, the significant processes of photography, and who invented the polaroid and photographic film. A timeline of tin cans - learn how cans are made, filled and recycled.
The history of the first can opener. Canadian inventors have patented more than one million inventions. The delectable history of candy. Edward Goodrich Acheson invented carborundum. Carborundum is the hardest man-made surface and was essential to ushering in the industrial age. The history of playing cards and card games like Uno. Wilson Greatbatch invented an implantable cardiac pacemaker. Carmex is a salve for chapped lips and cold sores invented in The history of the automobile covers over one hundred years.
Learn about the patents and famous car models, view timelines, read about the first gasoline powered car, or about electric vehicles. The interesting history behind the carousel and other circus and theme park innovations.
James Ritty invented what was nicknamed the "Incorruptible Cashier" or the cash register. In , the Philips company became the first company to demonstrate the compact audio cassette. Percy Shaw patented his road-safety invention called cat eyes, in when he was only Thomas Fogarty invented the embolectomy balloon catheter.
Betty Rozier and Lisa Vallino co-invented the intravenous catheter shield. Ingemar Henry Lundquist invented the over the wire balloon catheter that is used in the majority of angioplasty procedures in the world.
Electronic television is based on the invention of the cathode ray tube, which is the picture tube found in modern television sets. How the FCC slowed the progress of a cellular phone system. Cellophane film was invented by Jacques Brandenberger in Swedish astronomer, Anders Celsius invented the centigrade scale and celsius thermometer.
In , the First Census of the United States was taken. The history behind the humble chain saw. French monks were the first to bottle a sparkling form of wine called Champagne, named after the Champagne region of France. The history of Chapstick and its inventor. Pompoms and the history of cheerleading innovations. The history of "Cheese in a Can". The cheese-slicer is a Norwegian invention. Cheesecake is believed to have originated in ancient Greece. The history of chewing gum and bubble gum.
Animal figurines have been designed which have live herbs that simulate the fur or hair of a particular animal. The history behind chocolate, chocolate bars and chocolate chip cookies.
The history of candy canes, Christmas lights and Christmas trees. In , the first Christmas tree was lit by the use of electricity. This history of tobacco related products. The clarinet evolved from an earlier instrument called the chalumeau, the first true single reed instrument. Robert Fulton's steamboat, the Clermont, became the first successful steam-propelled vessel. The history of reproductive and therapeutic. Television closed captions are captions that are hidden in the television video signal, invisible without a special decoder.
The history of what we wear: blue jeans, the bikini, the tuxedo, fabrics, fasteners, and more. John Pemberton in The cochlear implant is a prosthetic replacement for the inner ear or cochlea. The history of the cultivation of coffee and innovations in brewing methods.
Viktor Schauberger was the "father of cold fusion energy" and the designer of the first non-energy consuming "flying disc". Color television was by no means a new idea, a German patent in contained the earliest proposal—RCA color television system—Living Color. Samuel Colt invented the first revolver aptly named the Colt revolver. History of the internal combustion engine. Rudolf Diesel was the father of the "diesel-fueled" internal combustion engine or diesel engine.
History, timeline, and innovations. James Russell invented the compact disc in Russell was granted a total of 22 patents for various elements of his system. The history of the magnetic compass. An index to famous persons in the computer business, over twenty-six fully illustrated features cover the history of computers from until today. Dietrich Prinz wrote the original chess playing program for a general purpose computer.
This history is more fun than a joy stick. Steve Russell invented the computer game called "SpaceWar. The invention of the modern computer keyboard began with the invention of the typewriter. Compact disks, the computer mouse, computer memory, disk drives, printers and other peripherals are discussed. The history of printers used with computers.
Concrete was invented by Joseph Monier. The history of construction and building materials. The history of corrective lenses—from the oldest known glass lens to modern contact lenses. Enjoy some snack food history and learn how the Fig Newton got named, how cotton candy works, and all about chocolate-chip cookies. Sir James Dewar was the co-inventor of cordite, a smokeless gunpowder. This illustrated history of cork extractors explains the origins of this humble invention, found in households all over the world.
The kooky history of Corn Flakes and other breakfast cereals. Percy Lavon Julian synthesized the medicines physostigmine for glaucoma and cortisone. Lewis Sarett invented a synthetic version of the hormone cortisone.
Eli Whitney patented the cotton gin on March 14, The cotton gin is a machine that separates seeds, hulls and other unwanted materials from cotton after it has been picked. See also: The Cotton Gin Patent. GM developed this test device nearly 20 years ago, to provide a biofidelic measurement tool -- a crash dummy that behaves very similarly to human beings.
The Crayola Company's founders invented the first crayon. Seymour Cray was the inventor of the Cray Supercomputer. Learn about credit, credit cards, and the first banks to issue them.
The crossword puzzle was invented by Arthur Wynne. Carl Sontheimer invented the Cuisinart. Ernest Lawrence invented the cyclotron, a device that greatly increased the speed with which projectiles could be hurled at atomic nuclei. Chester Greenwood , a grammar school dropout, invented earmuffs at the age of 15 to keep his ears warm while ice skating. Greenwood would go on to accumulate over patents in his lifetime. The history of ear plugs.
Inventions created for Easter occasions. In , Thomas Hancock patented elastic fastenings for gloves, suspenders, shoes and stockings. In , the first automatic electric blanket was invented. The history and of the electric chair. Several famous persons in the field of electricity and electrical theory are profiled. The history of electricity and electronics. Michael Faraday's big breakthrough in electricity development was his invention of the electric motor. An electric vehicle or EV by definition will use an electric motor for propulsion rather than being powered by a gasoline-powered motor.
An electromagnet is a device in which magnetism is produced by an electric current. Innovations related to magnetic fields. See Also - Timeline of Electromagnetism. The complex history behind the electron or vacuum tube.
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